Lipid microsphere composition and preparation method thereof

The invention relates to a lipid microsphere composition and a preparation method thereof. The lipid microsphere composition contains a pharmaceutical phospholipid complex, and contains egg yolk phosphatidylglycerol as a stabilizer, wherein phospholipid is egg yolk lecithin E80. According to the embodiment of the invention, the egg yolk lecithin E80 is selected to prepare the pharmaceutical phospholipid complex, and the egg yolk phosphatidylglycerol is selected as the stabilizer, so that the prepared lipid microsphere can remarkably improve the encapsulation efficiency and stability, and particularly has a better effect on medicines with poorer fat solubility. 本发明涉及一种脂质微球组合物及其制备方法。脂质微球组合物含有药物磷脂复合物，并且含有作为稳定剂的蛋黄磷脂酰甘油；其中，所述磷脂为蛋黄卵磷脂E80。本发明实施例选用蛋黄卵磷脂E80制成药物磷脂复合物，选用蛋黄磷脂酰甘油作为稳定剂，这样所制成的脂质微球可以显著地提高包封率和稳定性，尤其是对于脂溶性较差的药物效果更佳。