Preparation method of novel surface-enhanced Raman spectroscopy substrate

The invention discloses a preparation method of a novel surface-enhanced Raman spectroscopy (SERS) substrate, and belongs to the technical field of preparation of multifunctional nano materials. The invention aims to develop a nano material which can be used as a surface enhanced Raman spectrum substrate, and a preparation method for changing the microstructure of nano particles by adopting a metal ion doping technology. The method comprises the following steps: preparing ZrO2 nanoparticles doped with metal ions, carrying out surface modification on probe molecules, and examining the SERS performance of a substrate. A hydrothermal synthesis method is adopted, and the preparation process is simple; and the doping of the metal ions can improve the surface state of the substrate and can improve the SERS signal intensity. Compared with undoped ZrO2 nano particles, the metal ion doped ZrO2 nano particles prepared by adopting the preparation method disclosed by the invention have the advantage that the SERS signal