Novel double-stranded oligo RNA and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases

The present invention relates to a novel siRNA, and a highly efficient double-stranded oligo RNA structure comprising the same and nanoparticles comprising the highly efficient double-stranded oligo RNA structure, wherein the double-stranded oligo RNA structure is one in which a hydrophilic material and a hydrophobic material are conjugated to both terminals of the double-stranded RNA (siRNA) through a simple covalent bond or linker-mediated covalent bond to efficiently transport the double-stranded RNA structure into cells, and the double-stranded RNA structure may be changed into a nanoparticle form in an aqueous solution due to the hydrophobic interaction between the double-stranded RNA structures. The siRNA included in the double-stranded oligo RNA structure is preferably siRNA specific to a fibrosis or respiratory disease-associated gene, particularly, amphiregulin or stratifin. Further, the present invention relates to a pharmaceutical composition comprising siRNA, and a highly efficient double-stranded