Preparation method of glucosamine sulfate composite salt

The invention belongs to the field of pharmaceutical chemicals, and relates to a preparation method of glucosamine sulfate composite salt. The method comprises the following steps: adding N-acetylglucosamine and a solvent into a reaction vessel, wherein the concentration of N-acetylglucosamine in the reaction vessel is 0.5-60%; then adding sulfuric acid and a stabilizer, wherein the concentrationof the sulfuric acid is 1-90%, the mass ratio of the N-acetylglucosamine to the sulfuric acid is 1:(0.1-40), and the mass ratio of the N-acetylglucosamine to the stabilizer is 1:(0.2-2.4); carrying out the heat preservation reaction for 1-20 hours at a reaction temperature of 25-100 DEG C; and after the basic reaction is finished, carrying out treating to obtain the glucosamine sulfate composite salt. The glucosamine sulfate composite salt prepared through the method is simple in preparation method and process, low in cost and beneficial to industrial production, and the obtained finished product is stable in property