Substituted thiophene compound as well as preparation method and application thereof

The invention relates to a thiophene compound and pharmaceutically acceptable salts thereof represented by a general formula I, a preparation method thereof, a pharmaceutical composition containing the thiophene compound or pharmaceutically acceptable salts thereof, and applications of the thiophene compound and the pharmaceutically acceptable salts. The thiophene compound and the pharmaceuticallyacceptable salts thereof are used as a novel estrogen-related receptor alpha (ERR[alpha]) inverse agonist. The compound can be used to treat diseases associated with ERR and ERR[alpha], such as cancer, osteoporosis, diabetes, aging resistance, weight loss, and the like. After further optimization and screening, the compound is expected to be developed into a novel medicine for preventing and treating tumors or other ERR[alpha] related diseases. 本发明涉及一种通式I表示的噻吩类化合物及其药学上可用的盐、其制备方法、包含其的药物组合物及其用途。所述噻吩类化合物及其药学上可用的盐作为一种新型雌激素相关受体α(ERRα)反向激动剂。这些化合物能用来治疗与ERR和ERRα相关的疾病，如癌症、骨质疏松、糖尿病、抗衰老、减肥等。经过进一步的优化和筛选后，有望研发成为新型的预防及治疗肿瘤或其他ERRα相