TECHNIQUES FOR GENERATING CELL-BASED THERAPEUTICS USING RECOMBINANT T CELL RECEPTOR GENES

The present technology relates generally to compositions and methods for creating recombinant T cell receptor (TCR) libraries and methods of their therapeutic use. The compositions and methods of thepresent technology are useful for rapid isolation of antigen-specific TCR repertoires as personalized, targeted therapies for cancer and viral infection. 本技术大体上涉及用于产生重组T细胞受体(TCR)文库的组合物和方法，以及它们的治疗性应用方法。本技术的组合物和方法可用于快速分离抗原特异性TCR库，作为针对癌症和病毒感染的个性化靶向疗法。