Method for preparing halogenated methyl substituted pyrazole ring pesticide intermediate
The invention discloses a method for preparing a halogenated methyl substituted pyrazole ring pesticide intermediate, wherein the method comprises the steps: mixing a halogenated or non-halogenated lipid compound A and an alpha-H halogenated or non-halogenated ester compound B, putting into a reacto...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for preparing a halogenated methyl substituted pyrazole ring pesticide intermediate, wherein the method comprises the steps: mixing a halogenated or non-halogenated lipid compound A and an alpha-H halogenated or non-halogenated ester compound B, putting into a reactor, stirring, adding a base catalyst in batches to carry out Claisen condensation reaction, heating to 50-80 DEG C, and refluxing for about 1-5 hours, and recovering a solvent; adding an acidic solvent for acidification, cooling to 5-15 DEG C or below, dropwise adding methylhydrazine, keeping the temperature for 0.5-2 hours after completion of dropwise adding, heating to 50-80 DEG C, and keeping the temperature; and carrying out HPLC central control, recovering the acidic solvent, and adding water for desolventizing to obtain the pyrazole ring intermediate. The process disclosed by the invention has the advantages that an intermediate does not need to be separated and purified, the process operation flow is simplifi |
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