Oil-in-water type compound fluconazole nano-emulsion and preparation method thereof

The invention discloses an oil-in-water compound fluconazole nano-emulsion antifungal drug. The nanoemulsion has a droplet diameter between 1 and 100 nm and consists of the following raw materials inpercentage by mass: 25.00%-40.00% of a surfactant, 3.80%-10.00% of a cosurfactant, 3.00%-25.00% of oil, 0.05%-2.50% of fluconazole, 0.01%-0.70% of magnolol, and the balance of distilled water, and sumof the mass percentages of the above raw materials is 100%. The nano-emulsion preparation is clear and transparent liquid, has good stability, improves solubility of fluconazole, overcomes defect oflow bioavailability of fluconazole in vivo, delays metabolism time of fluconazole in vivo, reduces adjuvant dosage, reduces production cost, and has broad market prospects in the field of medicines. 本发明公开了一种水包油型复方酮康唑纳米乳抗真菌药物，该纳米乳液滴直径大小在1～100nm之间，由下列质量百分比的原料组成：表面活性剂25.00%～40.00%、助表面活性剂3.80%～10.00%、油3.00%～25.00%、酮康唑0.05%～2.50%，厚朴酚0.01%～0.70%，余量为蒸馏水，上述原料的质量百分比之和为100%。该纳米乳制剂是澄清透明液体，稳定性好，提高了酮康唑的溶解度，克服了其在体内生物利用度低的缺点，延缓其在体内的药物代谢时间