Non-invasive diagnostic marker for liver cirrhosis related to chronic drug-induced liver injury and application of non-invasive diagnostic marker

The invention discloses a non-invasive diagnostic marker for liver cirrhosis related to chronic drug-induced liver injury and application of the non-invasive diagnostic marker. Every two of the five discovered metabolites are combined to construct a peak area ratio or absolute quantification of the peak areas of the metabolites, so that the five discovered metabolites can be used for distinguishing a chronic DILI liver cirrhosis group from a non-liver cirrhosis chronic DILI group. At present, liver puncture pathological examination is a gold standard for liver cirrhosis diagnosis, but the liver puncture pathological examination is related to patient compliance and patient contraindications, and sometimes is difficult to implement; and due to invasive examination, the method is difficult tobe used as a dynamic monitoring and early diagnosis method of the LC-DILI. The non-invasive diagnostic marker and the application thereof provided by the invention can replace common invasive liver puncture pathological exam