CELL ENGAGING BINDING MOLECULES

CELL ENGAGING BINDING MOLECULES

The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present disclosure generally related to a binding molecule comprising antibody variable light (VL)regions, variable heavy (VH) regions, constant heavy 1 (CH1) regions, and light chain constant (CL) r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PARK BUMAN, PARK YOUNG-WOO, JANG SE-IL
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present disclosure generally related to a binding molecule comprising antibody variable light (VL)regions, variable heavy (VH) regions, constant heavy 1 (CH1) regions, and light chain constant (CL) regions that are configured to form two antigen binding Fab regions and an antigen binding Fv regionso that the binding molecule binds to two different antigens. 本公开广泛地涉及癌症免疫治疗领域。例如，本公开一般涉及结合分子，所述结合分子包括抗体可变轻链(VL)区、可变重链(VH)区、恒定重链1(CH1)区和轻链恒定(CL)区，其配置形成两个抗原结合Fab区和一个抗原结合Fv区，使所述结合分子结合两种不同的抗原。