Xanthohumol derivative, preparation method and application thereof

The invention relates to a xanthohumol derivative and a preparation method and application thereof, the xanthohumol derivative takes 1 '', 2'' dihydroxanthohumol C, xanthohumol C, 1 '', 2'' dihydroxanthohumol K as raw materials, and the raw materials react with different acyl chlorides under alkaline conditions to obtain a compound 1-22. The synthesized compound 1-22 is subjected to a preliminaryanti-inflammatory activity test. Experimental results show that the compounds 16 and 17 show certain anti-inflammatory activity, and the compounds 3, 15, 20, 21 and 22 show remarkable anti-inflammatory activity; wherein a compound 3 has a remarkable inhibition effect on a nuclear transcription factor kappa B signal path, can remarkably reduce expression of lipopolysaccharide-induced proinflammatory factor interleukin 1-beta genes and precursor protein levels, and can also remarkably inhibit secretion of interleukin 1-beta in lipopolysaccharide-induced marrow-derived macrophage inflammation. The compound can be used fo