Inhibitor for autophagy and apoptosis of retinal pigment cells RPE and application of inhibitor

The invention provides an inhibitor for autophagy and apoptosis of retinal pigment epithelial cells RPE and application of the inhibitor, and relates to the technical field of biological medicines. The invention relates to an inhibitor for autophagy and apoptosis of retinal pigment epithelial cells RPE. The inhibitor comprises an antagonist Met of a tumor necrosis factor superfamily receptor FAS.It is verified that the tumor necrosis factor superfamily receptor FAS can serve as a receptor of GMFB to activate downstream autophagy and apoptosis pathways, the antagonist Met of the tumor necrosisfactor superfamily receptor FAS can inhibit activation of the FAS and downstream related pathways of the FAS, cell apoptosis and autophagy reactions are reduced, and therefore the morbidity process of diabetic retinopathy is delayed. The inhibitor can be used for preparing medicines for delaying and/or treating diabetic retinopathy in the early stage of disease. 本发明提供了一种视网膜色素上皮细胞RPE的自噬和凋亡的抑制剂及其应用，涉及生物医药技术领域。本发明一种视网膜色素上皮细胞