Method for preparing N-(2-quinoline)-2-ketone compound under mild conditions

The invention discloses a method for preparing an N-(2-quinoline)-2-ketone compound under mild conditions, which belongs to the technical field of organic synthesis, and comprises the steps of weighing 2-hydroxy pyridine (or 2-hydroxy quinoxaline) and quinoline-N-oxide, uniformly dispersing in acetonitrile, adding an activating agent and carbon tetrachloride, and carrying out Atherton-Tod reactionunder the action of triethylamine, generating diethyl phosphoryl chloride in situ, then carrying out nucleophilic substitution reaction on diethyl phosphoryl chloride and quinoline-N-oxide, carryingout cross dehydrogenation coupling on the generated product and 2-hydroxypyridine (or 2-hydroxyquinoxaline), and carrying out aftertreatment on the reaction solution, thus finally obtaining the N-(2-quinoline)-2-pyridinone (or N-(2-quinoline)-2-quinoxaline) compound. The method provided by the invention mainly solves the problems of high reaction temperature, difficulty in preparation of reactionraw materials, long reactio