Rilpivirine hydrochloride impurity and synthesis method thereof

The invention relates to the field of medicinal chemistry, and relates to a related impurity of a rilpivirine starting material, a preparation method and a composition thereof. The impurity is specifically a compound 1. The invention discloses a new related impurity in the rilpivirine starting material, and the new related impurity can be used as a reference substance or other research institutesin subsequent quality detection. The quality research and quality control of the rilpivirine starting material are improved, so that the product quality control of the rilpivirine is improved. 本发明涉及药物化学领域，涉及利匹韦林起始物料的相关杂质、制备方法及其组合物，所述杂质具体为化合物1：本发明公开了利匹韦林起始物料中的新相关杂质，可用于后续质量检测中做对照品或其它研究所用，利于提高对利匹韦林起始物料的质量研究和质量控制，进而提高利匹韦林的产品质量控制。