New application of chloroquine

The invention discloses a new application of chloroquine. Chloroquine is used for preparing a chloroquine-containing drug for preventing or treating imatinib-resistant gastrointestinal stromal tumor,inhibiting downstream autophagy related PI3K/AKT/mTOR and MAPK pathways by up-regulating PTEN expression, improving the sensitivity of the gastrointestinal stromal tumor to imatinib and promoting cancer cell apoptosis. The dosage of chloroquine in drug-resistant gastrointestinal stromal tumor cells is 50 [mu] M, and the dosage of chloroquine in a corresponding nude mouse transplanted tumor model is 60 mg/kg/day. Chloroquine is a classic drug for resisting malaria, serves as a drug acting on autophagy lysosome in a targeted mode, and can block the last step of autophagy. Excessive autophagy isone of mechanisms of gastrointestinal stromal tumor on imatinib resistance, and seriously influences the curative effect. The new application can be used as a new strategy for overcoming the drug resistance of gastrointestinal