CHIMERIC ANTIGEN RECEPTORS TARGETING CD70

The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PANOWSKI SILER, GALETTO ROMAN ARIEL, DUSSEAUX MATHILDE BRUNNHILDE, NAGARAJAN NIRANJANA ADITI, PARK YOON, VAN BLARCOM THOMAS JOHN, SASU BARBRA JOHNSON, SRIVATSA SRINIVASAN SURABHI, SAI TAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment ofa condition associated with malignant cells expressing CD70 (e.g., cancer). 本公开提供了与CD70特异性结合的CAR(CAR)。本公开还涉及包含此类CAR的工程化免疫细胞，编码CAR的核酸，以及制备此类CAR、工程化免疫细胞和核酸的方法。本公开还涉及使用这些CAR和包含这些CAR的工程化免疫细胞治疗与表达CD70的恶性细胞相关的病状(例如，癌症)的治疗方法。