Osteochondral repair biomimetic material as well as preparation method and application thereof

The invention provides an osteochondral repair biomimetic material as well as a preparation method and application thereof. The osteochondral repair biomimetic material comprises a bone repair layer and a cartilage repair layer; and the bone repair layer comprises polymethyl methacrylate bone cement modified by hydrophilic and hydrophobic segment polymers, and the cartilage repair layer comprisesan elastomer obtained by polymerizing hydrophilic and hydrophobic segment polymers and methyl methacrylate. The osteochondral repair biomimetic material has mechanical properties matched with a bone environment and a cartilage environment, and also has the advantages of degradability, good biocompatibility and the like in a living body. 本发明提供一种骨软骨修复仿生材料及其制备方法和应用。所述骨软骨修复仿生材料包括骨修复层和软骨修复层；所述骨修复层包括亲疏水片段聚合物改性的聚甲基丙烯酸甲酯骨水泥，所述软骨修复层包括亲疏水片段聚合物与甲基丙烯酸甲酯聚合得到的弹性体。所述骨软骨修复仿生材料具有与骨环境和软骨环境相匹配的力学性能，而且在生物体内还具有可降解性及良好的生物相容性等诸多优点。