Adhesive antibacterial hemostatic sponge and preparation method thereof

The invention discloses an adhesive antibacterial hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared by the following steps: subjecting N-maleoyl chitosan, acrylamide, epsilon-polylysine, acrylate PEG-N hydroxysuccinimide ester and N,N'-hydroxysuccinimide ester to full reaction, adding acrylic acid and a first part of photoinitiator, carrying out prepolymerization, adding a mixed solution of acrylic acid N-hydroxysuccinimide ester and a second part of photoinitiator, carrying out full polymerizing, and carrying out program freeze-drying. The hemostatic spongeprepared by the invention not only can quickly absorb blood or penetrating fluid to form gel, compress damaged blood vessels on the surface of a cavity and promote hemostasis, but also can be adheredto the surface of the cavity, and prevents displacement while further promoting hemostasis. The hemostatic sponge disclosed by the invention can slowly release chitosan and epsilon-polylysine, and has a long-acting antibacter