TWO-PART NITRIC OXIDE GENERATING TOPICAL COMPOSITIONS

TWO-PART NITRIC OXIDE GENERATING TOPICAL COMPOSITIONS

A two-part topical composition includes a first composition including an S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to bemixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor a...

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Bibliographische Detailangaben
Hauptverfasser: QIN YU, DOVERSPIKE JOSHUA C, ZHOU YANG, MEYERHOFF MARK E, PHAN JAMES, WU JIANFENG, XI CHUANWU
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A two-part topical composition includes a first composition including an S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to bemixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20 DEG C to about 40 DEG C to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition. 两部分的局部组合物包括含S-亚硝基硫醇一氧化氮供体和载体的第一组合物，和含氧化锌的第二组合物。第二组合物将与第一组合物混合。氧化锌在大约20℃至大约40℃的温度下与S-亚硝基硫醇一氧化氮供体反应以提高从第一组合物和第二组合物的混合物中释放一氧化氮的速率。