COMPOSITION FOR ALLEVIATING SKIN BARRIER DYSFUNCTION

The present invention relates to a cosmetic composition for alleviating skin barrier dysfunction, a pharmaceutical composition for preventing or treating skin barrier dysfunction, a quasi-drug composition for preventing or alleviating skin barrier dysfunction, a method for alleviating skin barrier dysfunction, and a method for preventing or treating skin barrier dysfunction. According to the present invention, hydroxycinnamic acid, isoamyl acetate, or betaine promotes autophagy activation independently of the mTOR pathway and accelerates the turnover of the epidermis to increase the thicknessof the epidermis, thereby improving the barrier function and preventing the senescence-induced attenuation of the epidermis. 本发明涉及皮肤屏障功能异常的改善用化妆料组合物、皮肤屏障功能异常的预防或治疗用药学组合物、皮肤屏障功能异常的预防或改善用医药外品组合物、皮肤屏障功能异常的改善方法以及皮肤屏障功能异常的预防或治疗方法。通过本发明，羟基肉桂酸、乙酸异戊酯或甜菜碱独立于mTOR途径而促进角质形成细胞中的自噬作用活性并促进表皮的更替，从而可以通过增加表皮的厚度来改善屏障功能并防止老化导致的表皮层的弱化。