Novel molecular artemisinin derivative and synthesis method thereof

The invention discloses a novel molecular artemisinin derivative and a preparation method thereof. The novel molecular artemisinin derivative comprises molecules formed by a chemical reaction of dihydroartemisinin and derivatives thereof (a) and flavonoid compounds (b). The compound (a) of dihydroar...

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1. Verfasser: NI XUMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a novel molecular artemisinin derivative and a preparation method thereof. The novel molecular artemisinin derivative comprises molecules formed by a chemical reaction of dihydroartemisinin and derivatives thereof (a) and flavonoid compounds (b). The compound (a) of dihydroartemisinin and derivatives thereof has molecular structures of dihydroartemisinin and derivatives thereof; in the reaction, dihydroartemisinin and liquiritin derivatives are used as initial raw materials, PPh3, and a DIAD reagent take THF a solvent, temperature is controlled at 0 DEG C, an etherification reactionis carried out under normal pressure to generate a target product (c); after the reaction, a reaction solution is washed, a target object is extracted (c) by using chloroform; desolventizing is carried out, a target object is dissolved by using ethyl acetate, and recrystallizing is carried out; and finally, desolventizing is carried out to obtain a white powder pure product, the effective ingredients of the