Germacranolide derivatives and pharmaceutical compositions thereof and application of germacranolide derivatives, and pharmaceutical compositions in medicines

The invention relates to germacranolide derivatives and pharmaceutical compositions thereof, and application of the germacranolide derivatives and the pharmaceutical compositions in medicines. Specifically, the invention relates to the germacranolide compounddiscloses, a preparation method of the compounds, and application of the pharmaceutical composition with the compounds as active components in preparation of VEGF (vascular endothelial growth factor)-induced human umbilical cord endocrine (HUVEC) proliferation selective inhibitors and low-toxicity drugs for resisting angiogenesis-related diseases such as retinopathy and the like. 本发明涉及大根香叶衍生物及其药物组合物和其在医药中的用途。具体而言，本发明涉及一类大根香叶类化合物，其制备方法，及以该类化合物为活性成分的药物组合物在制备VEGF(血管内皮生长因子)诱导的人脐带内分泌(HUVEC)增殖选择性抑制剂中和视网膜病变等抗血管生成相关疾病的低毒性药物中的应用。