Submucosal injection solution composition for endoscope and preparation method

The invention relates to the technical field of injection reagent, in particular to a submucosal injection solution composition for an endoscope and a preparation method. The composition is prepared from 0.01 w/v% to 0.5 w/v% of hyaluronic acid, 0.005 w/v% to 0.5 w/v% of carboxymethyl chitosan, 0.001 w/v% to 0.1 w/v% of coloring agent and the balance of phosphate buffer solution, wherein the hyaluronic acid is selected from sodium hyaluronate, magnesium hyaluronate, calcium hyaluronate or zinc hyaluronate; the substitution degree of the carboxymethyl chitosan is greater than 0.85, and the dynamic viscosity of the carboxymethyl chitosan is 500-5000 mPa*s; and the coloring agent is selected from trypan blue, methylene blue, indigo blue, gentian violet or indocyanine green. The hyaluronic acid, the carboxymethyl chitosan and the coloring agent are combined for use, relatively long mucous membrane lifting time is kept, the lesion boundary is clearly displayed, postoperative bleeding and infection are reduced, and