Pan-cancer detection panel based on next-generation sequencing technology and application of detection panel
The invention belongs to the technical field of pan-cancer polygene detection and discloses a pan-cancer detection panel based on a next-generation sequencing technology. Important exon regions and partial intron regions of 141 genes are enriched by utilizing a gene probe hybridization method, so th...
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| creator | ZHANG QUNLING GUO WEIJIAN TAO ZHONGHUA ZHANG JIAN SHI JINXIU PEI YUCHEN WU XIANGHUA HU XIN CHANG JIANHUA ZHANG XIAOWEI WANG YUNJIN HU ZHIHUANG SHAO ZHIMIN HUANG WEI WANG JIALEI HU XICHUN LUO ZHIGUO CAO JUNNING |
| description | The invention belongs to the technical field of pan-cancer polygene detection and discloses a pan-cancer detection panel based on a next-generation sequencing technology. Important exon regions and partial intron regions of 141 genes are enriched by utilizing a gene probe hybridization method, so that accurate detection is achieved; and more importantly, a detection object is patient DNA, and ctDNA is combined with a gene panel to serve as an examination object, so that targeted detection can be realized, and the gene detection cost of a patient and the operation difficulty of an experimentercan be reduced. Meanwhile, a polygene screening list is made into a probe, and high-risk genes are detected in a targeted mode through hybridization capture sequencing, so that gene mutation with guiding significance for diagnosis and treatment can be detected more efficiently, and meanwhile certain tumor patients can be helped to participate in clinical trials. The pan-cancer detection panel hasimportant guiding signific |
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Important exon regions and partial intron regions of 141 genes are enriched by utilizing a gene probe hybridization method, so that accurate detection is achieved; and more importantly, a detection object is patient DNA, and ctDNA is combined with a gene panel to serve as an examination object, so that targeted detection can be realized, and the gene detection cost of a patient and the operation difficulty of an experimentercan be reduced. Meanwhile, a polygene screening list is made into a probe, and high-risk genes are detected in a targeted mode through hybridization capture sequencing, so that gene mutation with guiding significance for diagnosis and treatment can be detected more efficiently, and meanwhile certain tumor patients can be helped to participate in clinical trials. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | Pan-cancer detection panel based on next-generation sequencing technology and application of detection panel |
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