Methoxypolyethylene glycol-polylactic acid segmented copolymer, polymeric micelle drug and preparation method

The invention discloses a methoxypolyethylene glycol-polylactic acid segmented copolymer, a polymeric micelle drug and a preparation method, and relates to the technical field of pharmaceutical preparations. According to the preparation method disclosed by the invention, the methoxypolyethylene glycol-polylactic acid segmented copolymer with narrow molecular weight distribution is prepared by controlling the reaction temperature of a ring-opening polymerization reaction, and a polymeric micelle prepared from the methoxypolyethylene glycol-polylactic acid segmented copolymer is small in particle size, narrow in distribution and good in stability. 本发明公开了一种聚乙二醇单甲醚-聚乳酸嵌段共聚物、聚合物胶束药物以及制备方法，涉及药物制剂技术领域。本发明公开的制备方法通过控制开环聚合反应的反应温度制备窄分子量分布的聚乙二醇单甲醚-聚乳酸嵌段共聚物，采用该聚乙二醇单甲醚-聚乳酸嵌段共聚物制备的聚合物胶束，粒径小且分布窄，具有良好的稳定性。