Compound tablet containing atazanavir and ritonavir and preparation method of compound tablet

The invention relates to the field of pharmaceutical preparations, in particular to a compound tablet containing atazanavir and ritonavir and a preparation method of the compound tablet. According tothe method, the problems of poor thermal stability and poor water solubility of ritonavir in the compound tablets are solved by utilizing a hot melt extrusion technology, and the atazanavir and ritonavir compound tablet which is simpler in process difficulty, equipment conditions and process description control and better in bioavailability is researched and designed and is bioequivalent to singleatazonavir and ritonavir; and therefore, the medication mode is simplified, the patient compliance is improved, and the drug resistance risk is reduced. 本发明涉及药物制剂领域，具体涉及一种含有阿扎那韦和利托那韦的复方片剂及其制备方法。该方法利用热熔挤出技术，解决了在复方片剂中利托那韦热稳定性差和水溶性差的问题，并研究设计出一种工艺难度，设备条件，工艺阐述控制更简单，生物利用度更好的阿扎利托那韦复方片剂，并与单片阿扎那韦和利托那韦生物等效，从而简化用药方式，提高患者依从性，降低耐药风险。