ANTICOAGULANT PROTEINS AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH THE ACTIVATION OF NEUTROPHILS

The present invention relates to a protein or polypeptide comprising an Ixodes ricinus salivary gland polypeptide, a fragment or a variant thereof, and its use for inhibiting the extrinsic coagulationpathway and for treating and/or preventing diseases and conditions associated to the recruitment and activation of neutrophils following activation of the extrinsic coagulation pathway. In particular, the present invention relates to the use of a protein comprising an Ixodes ricinus salivary gland polypeptide, a fragment or a variant thereof, for the treatment and/or prevention of any thromboticevents associated with the recruitment and activation of neutrophils following activation of the extrinsic coagulation pathway. 本发明涉及包含蓖籽硬蜱唾液腺多肽、其片段或变体的蛋白质或多肽、及其在抑制外源性凝血途径中的用途和治疗和/或预防与外源性凝血途径活化后的中性粒细胞的募集和活化相关的疾病和病症中的用途。特别地，本发明涉及包含蓖籽硬蜱唾液腺多肽、其片段或变体的蛋白质用于治疗和/或预防与外源性凝血途径活化后的中性粒细胞的募集和活化相关的任何血栓形成事件的用途。