Pyrazinopyrazolonaphthyridine compound and preparation method and application thereof

The invention provides a pyrazinopyrazolonaphthyridine compound and a preparation method thereof. The compound is a raw material compound 2 prepared by reacting 2-bromo-1-(2-bromophenyl) ethanone prepared by reacting bromoacetophenone with N-bromosuccinimide with aryl formaldehyde hydrazone and vinyl tributyltin, and reacting with an aminopyrazinyl ketone compound 1 under the action of a metal catalyst and an oxidizing agent. The compound has good substrate universality, the reaction is a brand-new synthesis method proposed on the basis of the prior art, and the synthesized pyrazinopyrazolo naphthyridine compound has good antibacterial activity on escherichia coli, aspergillus niger, staphylococcus aureus and bacillus subtilis, and has profound significance on research and clinical use ofantibacterial drugs. 本发明提供一种吡嗪并吡唑并萘啶类化合物及其制备方法，该类化合物是由临溴苯乙酮与N-溴代丁二酰亚胺反应制备的2-溴-1-(2-溴苯基)乙酮与芳基甲醛腙及乙烯基三丁基锡反应制备原料化合物2，再与氨基吡嗪基酮类化合物1在金属催化剂及氧化剂的作用下反应制备的，该类化合物具有良好的底物普适性，该反应是在现有技术的基础上提供的一种全新的合成方法，合成的吡嗪并吡唑并萘啶类化合物对大肠杆菌、黑曲霉菌、金黄色葡萄球菌及枯草