Molecular probe for cancer diagnosis, application and synthesis method

The invention relates to the field of molecular detection, in particular to a molecular probe of an MELK inhibitor, provides a molecular probe of which the structure is shown as a chemical formula (I), and further provides application and a preparation method of the molecular probe. The molecular pr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TANG RONGMEI, HU JIA, HU FAN, GE YONGKANG, GONG CHENGPENG, LAN XIAOLI, LI KUN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of molecular detection, in particular to a molecular probe of an MELK inhibitor, provides a molecular probe of which the structure is shown as a chemical formula (I), and further provides application and a preparation method of the molecular probe. The molecular probe disclosed by the invention can be used for well imaging tumors with high MELK expression, particularly triple negative breast cancer, and is high in specificity and long in imaging duration. 本发明涉及分子检测领域,更具体地,涉及MELK抑制剂的分子探针,本发明提供了一种分子探针,其结构如化学式(I)所示,还提供了本发明分子探针的用途和制备方法。使用本发明的分子探针,能够很好的对MELK高表达的肿瘤成像,特别地,三阴性乳腺癌,其特异性高,成像持续时间长。