Regorafenib related substances as well as preparation method and application thereof

The invention relates to a synthesis method of regorafenib related substances B and C. According to the method, 4-chloro-N-methylpyridine-2-formamide, 4-amino-3-fluorophenol and potassium tert-butoxide are used as starting materials, and the two related substances are obtained through one synthesis...

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Bibliographische Detailangaben
Hauptverfasser:	WU LIHONG, SUN YUANPEI, WANG XIAOMENG, CHI XIAOLEI, LIANG MIN, XING QIANBIN, ZHONG WENHUI, JIA XIAOPENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The invention relates to a synthesis method of regorafenib related substances B and C. According to the method, 4-chloro-N-methylpyridine-2-formamide, 4-amino-3-fluorophenol and potassium tert-butoxide are used as starting materials, and the two related substances are obtained through one synthesis route, so time and cost are saved, and industrial production is easier. 本发明涉及一种瑞戈非尼有关物质B和C的合成方法，该方法以4-氯-N-甲基吡啶-2-甲酰胺、4-氨基-3-氟苯酚和叔丁醇钾为起始原料，通过一个合成路线得到两种有关物质，节约时间和成本，更易于工业化生产。