6-chloro-5-hydroxyisoindole-1-one and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and relates to 6-chloro-5-hydroxyisoindole-1-one and a synthesis method thereof. The preparation method of the compound comprises thefollowing steps: taking 1-bromo-4-methoxy-2-methyl benzene as a raw material, and carrying out halogen-lithium exchange, substitution, esterification, cross-linking, cyclization and substitution to prepare 6-chloro-5-hydroxyisoindole-1-one. According to the invention, an efficient synthesis method is provided for the synthesis of the compound. 本发明属于有机合成技术领域，涉及一种6-氯-5-羟基异吲哚-1-酮及其合成方法。该发明所述的化合物的方法为：以1-溴-4-甲氧基-2-甲基苯为原料，经卤素-锂交换、取代、酯化、交联、环化及取代反应六步反应制备了6-氯-5-羟基异吲哚-1-酮，为该化合物的合成提供了一种高效合成的方法。