Application of stem cell-derived microvesicles in preparation of preparation for repairing scars

The invention provides application of stem cell-derived microvesicles in preparation of a preparation for repairing scars, and relates to the technical field of scar skin repair. In the invention, theextracellular vesicles derived from the mesenchymal stem cells obviously inhibit the expression of c...

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Bibliographische Detailangaben
Hauptverfasser: LI YING'AO, JIA QINGZHI, ZHANG BIN, BIE QINGLI, WU PEIPEI, WEI DONG, CHEN YANRONG, GAN LIJUN, BAN BO, XIE NA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides application of stem cell-derived microvesicles in preparation of a preparation for repairing scars, and relates to the technical field of scar skin repair. In the invention, theextracellular vesicles derived from the mesenchymal stem cells obviously inhibit the expression of collagen III, the collagen III in the treatment group of the high-concentration microvesicles and the low-concentration microvesicles is obviously lower than that in the PBS group, and the expression of collagen I also presents a decreasing trend; both the high-concentration microvesicles and the low-concentration microvesicles can promote reasonable distribution of a skin structure, specifically, the structure of collagen is more reasonable, and accessory structures are remarkably increased; therefore, the stem cell-derived microvesicles have a scar repairing effect, the low-concentration microvesicles and the high-concentration microvesicles can promote the repairing effect of scar skin, the scar area of the repai