BISPECIFIC ANTIBODY TO A-SYN/IGF1R AND USE THEREOF

The present invention relates to a bispecific antibody binding specifically to alpha-synuclein and IGF1R and a use of the bispecific antibody in preventing, treating, and/or diagnosing alpha-synucleinopathies, which are diseases related to alpha-synuclein or an aggregate thereof. In the present inve...

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Bibliographische Detailangaben
Hauptverfasser:	YEOM DONG-HOON, KIM YEUN-JU, SONG DAE-HAE, AHN JIN-HYUNG, SUNG EUN-SIL, EOM JAE-HYUN, JUNG JAE-HO, SON YONG-GYU, YOU WEON-KYOO, LEE BO-RA, LEE YO-SEOB, YOO JI-SEON, JUNG JIN-WON, KIM JU-HEE, CHUNG HYE-JIN, SUNG BYUNG-JE, AN SUN-GWON, PARK KYUNG-JIN, AHN SEA-WON, PAK YOUNG-DON, KIM DONG-IN, LEE SANG-HOON
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a bispecific antibody binding specifically to alpha-synuclein and IGF1R and a use of the bispecific antibody in preventing, treating, and/or diagnosing alpha-synucleinopathies, which are diseases related to alpha-synuclein or an aggregate thereof. In the present invention, an a-syn antibody or an antigen binding fragment thereof is allowed to pass the blood-brain barrier and to exert the function thereof in the brain, and the half-life is prolonged so that the medicinal efficacy can be maintained for a long period of time. 本发明涉及与α-突触核蛋白和IGF1R特异性结合的双特异性抗体，以及该双特异性抗体在预防、治疗和/或诊断α-突触核蛋白病中的用途，α-突触核蛋白病是与α-突触核蛋白或α-突触核蛋白聚集体相关的疾病。本发明中，允许α-syn抗体或其抗原结合片段穿透血脑屏障以在脑中发挥其作用，并延长半衰期使得可以长时间维持药学功效。