Construction method of model for predicting curative effect of PD-1

The invention discloses a construction method of a model for predicting the curative effect of PD1. The construction method comprises the following steps of 1) selecting RNA-seq of a puncture or paraffin tissue sample within one month before medication as a baseline, and ensuring that a patient is not subjected to other treatments during the period; 2) after the patient is subjected to PD-1/PD-L1treatment, performing CT scanning every three months; 3) performing conventional RNA-seq sequencing on the sample; (4) analyzing RNA-seq biological information; 5) constructing and screening RNA-seq data characteristics for predicting the curative effect of the PD-1; and 6) constructing the model for predicting the curative effect of the PD-1. Compared with a conventional PD-1 curative effect prediction molecular marker , an RNA sequencing molecular marker is more accurate in prediction result, and lower in cost. 本发明公开了一种用于预测PD-1疗效的模型的构建方法，包括如下步骤：1)选取用药时间前一个月内穿刺或石蜡组织的样本的RNA-seq作为基线，患者在此期间内未接受其他治疗；2)患者进行PD-1/PD-L1治疗后，每