Thiazole derivative and synthesis method thereof

The invention belongs to the technical field of organic synthesis, particularly relates to a thiazole derivative and a synthetic method thereof, and particularly relates to a thiazole derivative (Z)-4-((2-(2-(2-(2,5-dimethoxyphenyl)-thiazole-5-yl)-ethylimino)(phenyl)methyl)-1,3-benzenediol and a synthetic method thereof. The synthesis method provided by the invention comprises the following steps:by taking 2,5-dimethoxybenzamide and ethyl 2-chloroacetate as raw materials, carrying out six reaction steps of carbonyl sulfide reaction, substitution, cyclization, substitution, chlorination, cyanidation, amidation, hydrolysis and substitution reaction to prepare the (Z)-4-((2-(2-(2-(2,5-dimethoxyphenyl)-thiazole-5-yl)-ethylimino)(phenyl)methyl)-1,3-benzenediol. According to the invention, an efficient synthesis method is provided for the synthesis of the thiazole derivative. 本发明属于有机合成技术领域，具体涉及一种噻唑类衍生物及其合成方法，特别是涉及一种噻唑类衍生物(Z)-4-((2-(2-(2-(2,5-二甲氧基苯基)噻唑-5基)乙基亚氨基)(苯基)甲基)-1,3-苯二酚及其合成方法，本发明提供的合成方法为：以2,5-二甲氧基苯甲酰胺和2-氯乙酸乙酯