Surface-modified mesoporous silica nanoparticles, method for producing same, and use thereof

The present disclosure relates to surface-modified mesoporous silica nanoparticles for blood-brain barrier penetration, tumor targeting, and cancer metastasis treatment, methods of making and uses thereof. Specifically, the invention relates to mesoporous silica nanoparticles MSN with specific modification, which have tumor targeting and blood-brain barrier BBB penetration properties as a drug delivery system, and are suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to a method of preparing an MSN and an MSN prepared by the method as described herein. 本公开涉及用于血脑屏障穿透、肿瘤靶向和癌症转移治疗的表面修饰的介孔二氧化硅纳米粒子、其制造方法及用途。具体地说，涉及具有特定修饰的介孔二氧化硅纳米粒子MSN，其作为药物递送系统，具有肿瘤靶向和血脑屏障BBB穿透性质，适合于癌症治疗和/或CNS疾病治疗。本公开还涉及制备MSN的方法和通过如本文所述的方法制备的MSN。