Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs

Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs

The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflamm...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KUANG QIXUAN, WANG LINA, CHEN JINFENG, DENG YUN, GUO DALE, TAN LU
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator KUANG QIXUAN
WANG LINA
CHEN JINFENG
DENG YUN
GUO DALE
TAN LU
description The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN111808153A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN111808153A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN111808153A3</originalsourceid><addsrcrecordid>eNqNjUEKwjAQRbNxIeodxgMUDEXoVoriRlfu65BOaiCdGZJ00dtb0QO4eHx4fHhr87wJS6GkxARDnJ3k0BM4GVUm7gE_qMbgsARhKC9KJB4CgyZSTF-9GOQSqsA-4jhikTRDn6Yhb83KY8y0--3G7C_nR3utSKWjrOiWcunau7W2OTT2WJ_qfz5vUWQ-SQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs</title><source>esp@cenet</source><creator>KUANG QIXUAN ; WANG LINA ; CHEN JINFENG ; DENG YUN ; GUO DALE ; TAN LU</creator><creatorcontrib>KUANG QIXUAN ; WANG LINA ; CHEN JINFENG ; DENG YUN ; GUO DALE ; TAN LU</creatorcontrib><description>The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla</description><language>chi ; eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20201023&amp;DB=EPODOC&amp;CC=CN&amp;NR=111808153A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20201023&amp;DB=EPODOC&amp;CC=CN&amp;NR=111808153A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUANG QIXUAN</creatorcontrib><creatorcontrib>WANG LINA</creatorcontrib><creatorcontrib>CHEN JINFENG</creatorcontrib><creatorcontrib>DENG YUN</creatorcontrib><creatorcontrib>GUO DALE</creatorcontrib><creatorcontrib>TAN LU</creatorcontrib><title>Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs</title><description>The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEKwjAQRbNxIeodxgMUDEXoVoriRlfu65BOaiCdGZJ00dtb0QO4eHx4fHhr87wJS6GkxARDnJ3k0BM4GVUm7gE_qMbgsARhKC9KJB4CgyZSTF-9GOQSqsA-4jhikTRDn6Yhb83KY8y0--3G7C_nR3utSKWjrOiWcunau7W2OTT2WJ_qfz5vUWQ-SQ</recordid><startdate>20201023</startdate><enddate>20201023</enddate><creator>KUANG QIXUAN</creator><creator>WANG LINA</creator><creator>CHEN JINFENG</creator><creator>DENG YUN</creator><creator>GUO DALE</creator><creator>TAN LU</creator><scope>EVB</scope></search><sort><creationdate>20201023</creationdate><title>Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs</title><author>KUANG QIXUAN ; WANG LINA ; CHEN JINFENG ; DENG YUN ; GUO DALE ; TAN LU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111808153A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>KUANG QIXUAN</creatorcontrib><creatorcontrib>WANG LINA</creatorcontrib><creatorcontrib>CHEN JINFENG</creatorcontrib><creatorcontrib>DENG YUN</creatorcontrib><creatorcontrib>GUO DALE</creatorcontrib><creatorcontrib>TAN LU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUANG QIXUAN</au><au>WANG LINA</au><au>CHEN JINFENG</au><au>DENG YUN</au><au>GUO DALE</au><au>TAN LU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs</title><date>2020-10-23</date><risdate>2020</risdate><abstract>The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN111808153A
source esp@cenet
subjects CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
title Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T13%3A47%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KUANG%20QIXUAN&rft.date=2020-10-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN111808153A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true