Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs

The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflamm...

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Hauptverfasser: KUANG QIXUAN, WANG LINA, CHEN JINFENG, DENG YUN, GUO DALE, TAN LU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla