Monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs
The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflamm...
Gespeichert in:
Hauptverfasser: | , , , , , |
---|---|
Format: | Patent |
Sprache: | chi ; eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The invention discloses a monoterpene glycoside compound and application thereof in preparation of anti-inflammatory drugs, and particularly provides a compound shown in a formula I, or salt of the compound, or a solvate of the compound, and application of the compound in preparation of anti-inflammatory drugs. Experimental results show that the compound shown in the formula I is separated from dry roots of sanguisorba officinalis plants, and compounds 1-4 are specifically obtained. Experiments prove that the compound can significantly reduce nitric oxide and inflammatory factors (including IL-6 and TNF-alpha) secreted by lipopolysaccharide-induced RAW264.7 macrophages, has a good protective effect on macrophage inflammatory response, and has significant in-vitro anti-inflammatory activity. In addition, the compound can effectively inhibit migration of inflammatory zebra fish macrophages, and has good in-vivo anti-inflammatory activity. The compound has a good application prospect in preparation of anti-infla |
---|