Quetiapine artificial hapten, artificial antigen and preparation method and application thereof

The invention discloses a quetiapine artificial hapten, an artificial antigen as well as a preparation method and application thereof. The molecular structural formula of the quetiapine artificial hapten is shown as a formula (I), and the molecular structural formula of the quetiapine artificial antigen is shown as a formula (II). According to the quetiapine artificial hapten, the characteristic structure of quetiapine is reserved to the maximum extent, and the quetiapine artificial hapten has an active group capable of being coupled with carrier protein and can be used as an antigen determinant; the further prepared quetiapine artificial antigen can be immunized to obtain an anti-quetiapine antibody with high affinity, high sensitivity and strong specificity, the titer of immune ascites obtained by immunizing Balb/c mice reaches up to 1: 78000, and the quetiapine artificial antigen can be used for rapid and accurate immunodetection and immunoassay of quetiapine. 本发明公开了一种喹硫平人工半抗原、人工抗原及其制备方法和应用。喹硫平人工半抗原的分子结构式如