Intermediate for preparing trifloxystrobin and synthesis method of intermediate

The invention relates to an intermediate for preparing trifloxystrobin and a synthesis method of the intermediate, wherein the synthesis method comprises the steps: by taking 2-oxime-o-methyl phenylacetonitrile as a raw material, heating and hydrolyzing in an alkaline aqueous solution to obtain 2-ox...

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Bibliographische Detailangaben
Hauptverfasser: LI XINMING, YANG XIANWEN, ZHANG YANBIN, CAI FANPING, FU YU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an intermediate for preparing trifloxystrobin and a synthesis method of the intermediate, wherein the synthesis method comprises the steps: by taking 2-oxime-o-methyl phenylacetonitrile as a raw material, heating and hydrolyzing in an alkaline aqueous solution to obtain 2-oxime-o-methyl phenylacetic acid or mono-sodium salt/mono-potassium salt or disodium salt/di-potassiumsalt of 2-oxime-o-methyl phenylacetic acid; and under an alkaline condition, carrying out a reaction with a methylation reagent to obtain (E)-2-(methoxyimine)-methyl o-methyl phenyl acetate. The method has the characteristics of easily available raw materials, single trans-configuration of the product, and simple operation, and is suitable for industrial production. 本发明涉及一种用于制备肟菌酯的中间体及其合成方法,以2-肟-邻甲基苯乙腈为原料,在碱水溶液中加热水解,得到2-肟-邻甲基苯乙酸或其单钠盐/单钾盐或双钠盐/双钾盐;在碱性条件下,与甲基化试剂反应,得到(E)-2-(甲氧亚胺)-邻甲基苯乙酸甲酯。本发明具有原料易得,产物为单一反式构型,且操作简便的特点,适合工业化生产。