Preparation method of larotinib intermediate, and intermediate compound

The invention discloses a preparation method of a larotinib intermediate represented by V, and an intermediate compound. The method comprises the following steps: taking 2,5-difluorobromobenzene and N-tert-butoxycarbonyl-L-pyroglutamate as initial raw materials, and carrying out coupling, deprotection group cyclization, reduction and decarboxylation to obtain a compound represented by a formula V.According to the invention, the preparation method has the advantages of novelty, low cost, cheap and easily available raw materials and high yield, and is suitable for large-scale industrial production. 本发明公开了一种如V所示拉罗替尼中间体的制备方法以及中间体化合物，该方法包括以2，5-二氟溴苯与N-叔丁氧羰基-L-焦谷氨酸酯为起始原料，进行偶联，脱保护基关环，还原，脱羧得到式V所示的化合物。本发明的制备方法新颖，成本低，原料廉价易得，产率高，适于大规模工业化生产。