Oocyte in-vitro maturation culture solution additive and application thereof

The invention discloses an oocyte in-vitro maturation culture solution additive. The in-vitro maturation culture solution additive contains ceruloplasmin. Therefore, a first polar body excretion rateof oocytes can be significantly increased, the ROS content of the oocytes can be significantly reduced, and the embryonic blastocyst rate after parthenogenetic activation can be significantly increased, so that the maturation rate and quality of the oocytes can be greatly improved. 本发明公开了一种卵母细胞体外成熟培养液添加剂，该添加剂包括铜蓝蛋白。由此，可以显著提高卵母细胞第一极体排出率、显著降低卵母细胞ROS含量，显著提高孤雌激活后胚胎囊胚率，由此可以大大提高卵母细胞的成熟率和质量。