Eutectic crystal of regorafenib and pimelic acid and preparation method thereof

The invention discloses a eutectic crystal of regorafenib and pimelic acid and a preparation method thereof. The molar ratio of regorafenib to pimelic acid in the eutectic crystal is 1: 1, and an X-ray powder diffraction pattern of the eutectic crystal has characteristic peaks when 2[theta] values are 7.9 +/-0.2 degrees, 11.2 +/-0.2 degrees, 16.7 +/-0.2 degrees, 19.7 +/-0.2 degrees and 24.1 +/-0.2degrees. The preparation method is simple in process, easily controls the crystallization process, is good in reproducibility and is suitable for industrial production. Compared with regorafenib monohydrate, the eutectic crystal has lower hygroscopicity and higher apparent solubility, and is beneficial to improving the stability and oral absorption efficiency of regorafenib. 本发明公开了一种瑞戈非尼与庚二酸共晶及其制备方法。该共晶中瑞戈非尼与庚二酸的摩尔比为1∶1，该共晶X射线粉末衍射图在2theta值为7.9±0.2°、11.2±0.2°、16.7±0.2°、19.7±0.2°、24.1±0.2°处具有特征峰。本发明提供的共晶制备方法工艺简单，结晶过程易于控制，重现性好，适用于工业化生产。这种共晶较瑞戈非尼一水合物具有较低的吸湿性，较高的表观溶解度，有利于提高瑞戈非尼的稳定性和口服吸收效率。