PATHOGEN REDUCED PLATELET COMPOSITIONS AND RELATED METHODS

Disclosed are methods for treating platelet compositions (e.g. platelet concentrates and/or platelet lysates) with electron beam radiation, where the compositions are in a frozen state during irradiation with the e-beam radiation. The methods can be conducted using e-beam radiation at doses effective to reduce the pathogen content of the compositions while retaining highly beneficial bioactivitiesof the compositions. Also disclosed are compositions preparable by the methods, and methods and compositions involving the use of the e-beam treated materials. 公开了用电子束辐射处理血小板组合物(例如，血小板浓缩物和/或血小板裂解物)的方法，其中在用电子束辐射照射期间组合物处于冷冻状态。所述方法可以使用有效剂量的电子束辐射进行，以减少组合物的病原体含量、同时保持组合物的高度有益的生物活性。还公开了可通过所述方法制备的组合物、以及涉及使用电子束处理的材料的方法和组合物。