Annullatins series natural product as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry, and relates to a cordyceps sinensis secondary metabolite Annullatins series natural product as well as a preparation method and application of the cordyceps sinensis secondary metabolite Annullatins series natural product. A total synthesis route is designed and established through experiments, commercially available raw materials are taken as a substrate, and the preparation of Annullatins series natural product is completed through mild reaction. According to the invention, an in-vitro anti-diabetic vascular complication activity test shows that the Annullatins series natural product designed by the invention plays a role in protecting vascular endothelial cells induced by high glucose, and is beneficial to prevention and treatment of diabetic vascular complication clinically. The Annullatins series natural product has a structural general formula shown in the specification. 本发明属药物化学领域，涉及一种虫草次生代谢产物Annullatins系列天然物及其制备方法和应用。通过实验，设计和建立了全合成路线，以市售易得原料为底