Preparation method and application of ortho-carbonyl amino substituted benzene derivatives
The invention discloses a compound shown as a formula (I) and a preparation method and application thereof; and especially discloses a compound shown as a formula (I), a stereoisomer, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, which can inhibit the enzyme activation...
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| creator | WEN HUI JI MING HAN JIANYI GAO YONGXIN WANG TING CUI HUAQING WANG YUCHEN ZHANG TINGTING SHENG LI LAI FANGFANG YIN DALI WANG SHUFANG LI YAN CHEN XIAOGUANG MA CHEN |
| description | The invention discloses a compound shown as a formula (I) and a preparation method and application thereof; and especially discloses a compound shown as a formula (I), a stereoisomer, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, which can inhibit the enzyme activation of human indoleamine 2,3-dioxygenase (IDO) and/or human tryptophan2,3-dioxygenase (TDO). The invention relates to the application of the compound in preparation of medicine for treating and/or preventing diseases or symptoms related to too high or overexpression of IDO/TDO activity, such as medicine for treating tumors. The compound provided by the invention has relatively strong IDO inhibitory activity.
本发明公开了具有式(I)所示的化合物及其制备方法和用途。具体的说，本发明进一步公开了含有如式(I)所示化合物、立体异构体、药学上可接受的盐及其药物组合物，他们能抑制人吲哚胺2，3-双加氧酶(IDO)和/或人色氨酸2，3-双加氧酶(TDO)的酶活性的作用，在制备用于治疗和/或预防与IDO/TDO活性过高或者过度表达有关的疾病或病症药物中的用途，如治疗肿瘤药物。本发明化合物具有较强的IDO抑制活性。 |
| format | Patent |
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本发明公开了具有式(I)所示的化合物及其制备方法和用途。具体的说，本发明进一步公开了含有如式(I)所示化合物、立体异构体、药学上可接受的盐及其药物组合物，他们能抑制人吲哚胺2，3-双加氧酶(IDO)和/或人色氨酸2，3-双加氧酶(TDO)的酶活性的作用，在制备用于治疗和/或预防与IDO/TDO活性过高或者过度表达有关的疾病或病症药物中的用途，如治疗肿瘤药物。本发明化合物具有较强的IDO抑制活性。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201013&DB=EPODOC&CC=CN&NR=111763164A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201013&DB=EPODOC&CC=CN&NR=111763164A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WEN HUI</creatorcontrib><creatorcontrib>JI MING</creatorcontrib><creatorcontrib>HAN JIANYI</creatorcontrib><creatorcontrib>GAO YONGXIN</creatorcontrib><creatorcontrib>WANG TING</creatorcontrib><creatorcontrib>CUI HUAQING</creatorcontrib><creatorcontrib>WANG YUCHEN</creatorcontrib><creatorcontrib>ZHANG TINGTING</creatorcontrib><creatorcontrib>SHENG LI</creatorcontrib><creatorcontrib>LAI FANGFANG</creatorcontrib><creatorcontrib>YIN DALI</creatorcontrib><creatorcontrib>WANG SHUFANG</creatorcontrib><creatorcontrib>LI YAN</creatorcontrib><creatorcontrib>CHEN XIAOGUANG</creatorcontrib><creatorcontrib>MA CHEN</creatorcontrib><title>Preparation method and application of ortho-carbonyl amino substituted benzene derivatives</title><description>The invention discloses a compound shown as a formula (I) and a preparation method and application thereof; and especially discloses a compound shown as a formula (I), a stereoisomer, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, which can inhibit the enzyme activation of human indoleamine 2,3-dioxygenase (IDO) and/or human tryptophan2,3-dioxygenase (TDO). The invention relates to the application of the compound in preparation of medicine for treating and/or preventing diseases or symptoms related to too high or overexpression of IDO/TDO activity, such as medicine for treating tumors. The compound provided by the invention has relatively strong IDO inhibitory activity.
本发明公开了具有式(I)所示的化合物及其制备方法和用途。具体的说，本发明进一步公开了含有如式(I)所示化合物、立体异构体、药学上可接受的盐及其药物组合物，他们能抑制人吲哚胺2，3-双加氧酶(IDO)和/或人色氨酸2，3-双加氧酶(TDO)的酶活性的作用，在制备用于治疗和/或预防与IDO/TDO活性过高或者过度表达有关的疾病或病症药物中的用途，如治疗肿瘤药物。本发明化合物具有较强的IDO抑制活性。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIgKKEotSCxKLMnMz1PITS3JyE9RSMwD4oKCnMxkiHB-mkJ-EVBGNzmxKCk_rzJHITE3My9fobg0qbgks6S0JDVFISk1ryo1L1UhJbUoswyorSy1mIeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCYDNZTEO_sZGhqamxkbmpk4GhOjBgCj7TwT</recordid><startdate>20201013</startdate><enddate>20201013</enddate><creator>WEN HUI</creator><creator>JI MING</creator><creator>HAN JIANYI</creator><creator>GAO YONGXIN</creator><creator>WANG TING</creator><creator>CUI HUAQING</creator><creator>WANG YUCHEN</creator><creator>ZHANG TINGTING</creator><creator>SHENG LI</creator><creator>LAI FANGFANG</creator><creator>YIN DALI</creator><creator>WANG SHUFANG</creator><creator>LI YAN</creator><creator>CHEN XIAOGUANG</creator><creator>MA CHEN</creator><scope>EVB</scope></search><sort><creationdate>20201013</creationdate><title>Preparation method and application of ortho-carbonyl amino substituted benzene derivatives</title><author>WEN HUI ; JI MING ; HAN JIANYI ; GAO YONGXIN ; WANG TING ; CUI HUAQING ; WANG YUCHEN ; ZHANG TINGTING ; SHENG LI ; LAI FANGFANG ; YIN DALI ; WANG SHUFANG ; LI YAN ; CHEN XIAOGUANG ; MA CHEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111763164A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WEN HUI</creatorcontrib><creatorcontrib>JI MING</creatorcontrib><creatorcontrib>HAN JIANYI</creatorcontrib><creatorcontrib>GAO YONGXIN</creatorcontrib><creatorcontrib>WANG TING</creatorcontrib><creatorcontrib>CUI HUAQING</creatorcontrib><creatorcontrib>WANG YUCHEN</creatorcontrib><creatorcontrib>ZHANG TINGTING</creatorcontrib><creatorcontrib>SHENG LI</creatorcontrib><creatorcontrib>LAI FANGFANG</creatorcontrib><creatorcontrib>YIN DALI</creatorcontrib><creatorcontrib>WANG SHUFANG</creatorcontrib><creatorcontrib>LI YAN</creatorcontrib><creatorcontrib>CHEN XIAOGUANG</creatorcontrib><creatorcontrib>MA CHEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WEN HUI</au><au>JI MING</au><au>HAN JIANYI</au><au>GAO YONGXIN</au><au>WANG TING</au><au>CUI HUAQING</au><au>WANG YUCHEN</au><au>ZHANG TINGTING</au><au>SHENG LI</au><au>LAI FANGFANG</au><au>YIN DALI</au><au>WANG SHUFANG</au><au>LI YAN</au><au>CHEN XIAOGUANG</au><au>MA CHEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method and application of ortho-carbonyl amino substituted benzene derivatives</title><date>2020-10-13</date><risdate>2020</risdate><abstract>The invention discloses a compound shown as a formula (I) and a preparation method and application thereof; and especially discloses a compound shown as a formula (I), a stereoisomer, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, which can inhibit the enzyme activation of human indoleamine 2,3-dioxygenase (IDO) and/or human tryptophan2,3-dioxygenase (TDO). The invention relates to the application of the compound in preparation of medicine for treating and/or preventing diseases or symptoms related to too high or overexpression of IDO/TDO activity, such as medicine for treating tumors. The compound provided by the invention has relatively strong IDO inhibitory activity.
本发明公开了具有式(I)所示的化合物及其制备方法和用途。具体的说，本发明进一步公开了含有如式(I)所示化合物、立体异构体、药学上可接受的盐及其药物组合物，他们能抑制人吲哚胺2，3-双加氧酶(IDO)和/或人色氨酸2，3-双加氧酶(TDO)的酶活性的作用，在制备用于治疗和/或预防与IDO/TDO活性过高或者过度表达有关的疾病或病症药物中的用途，如治疗肿瘤药物。本发明化合物具有较强的IDO抑制活性。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Preparation method and application of ortho-carbonyl amino substituted benzene derivatives |
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