Preparation method and application of ortho-carbonyl amino substituted benzene derivatives

The invention discloses a compound shown as a formula (I) and a preparation method and application thereof; and especially discloses a compound shown as a formula (I), a stereoisomer, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, which can inhibit the enzyme activation of human indoleamine 2,3-dioxygenase (IDO) and/or human tryptophan2,3-dioxygenase (TDO). The invention relates to the application of the compound in preparation of medicine for treating and/or preventing diseases or symptoms related to too high or overexpression of IDO/TDO activity, such as medicine for treating tumors. The compound provided by the invention has relatively strong IDO inhibitory activity. 本发明公开了具有式(I)所示的化合物及其制备方法和用途。具体的说，本发明进一步公开了含有如式(I)所示化合物、立体异构体、药学上可接受的盐及其药物组合物，他们能抑制人吲哚胺2，3-双加氧酶(IDO)和/或人色氨酸2，3-双加氧酶(TDO)的酶活性的作用，在制备用于治疗和/或预防与IDO/TDO活性过高或者过度表达有关的疾病或病症药物中的用途，如治疗肿瘤药物。本发明化合物具有较强的IDO抑制活性。