Production method of D-pantoic acid lactone

The invention belongs to the technical field of biosynthesis, and particularly relates to a production method of D-pantoic acid lactone, which comprises the following steps: preparing D-pantoic acid calcium by using DL-pantoic acid lactone and a calcium-containing compound as raw materials, and adding an acidic solution to perform acidolysis on the D-pantoic acid calcium, thereby obtaining a D-pantoic acid lactone solution. According to the D-pantolactone prepared by adopting the scheme, the optical purity of the obtained D-pantolactone is high, the production method is simple, the L-pantolactone can still be recycled, particularly, high cost and high pollution caused by extracting an intermediate product by adopting an organic solvent are avoided, and the D-pantolactone is suitable for being vigorously popularized in industrial mass production. 本发明属于生物合成技术领域，尤其涉及一种D-泛解酸内酯的生产方法，以DL-泛解酸内酯和含钙化合物为原料制备D-泛解酸钙，再加入酸性溶液将D-泛解酸钙酸解，即得D-泛解酸内酯溶液。采用上述方案制备的D-泛解酸内酯，所得D-泛解酸内酯光学纯度高，生产方法简单，L-泛解酸内酯仍然可以回收利用，尤其是避免了采用有机溶剂萃取中间产物而导致的