FC-binding fragment comprising PD-L1 antigen-binding site

The application relates to specific binding members which bind to programmed death-ligand (PD-L1). The specific binding members preferably comprise a PD-L1antigen-binding site located in structural loops of a constant domain of the specific binding member. The specific binding members find application, for example, in the treatment of cancer, as well as infectious diseases, inflammation, diseasesand conditions associated with inflammation, and inflammatory diseases. 本申请涉及特异性结合元件，其结合至程序性死亡配体(PD-L1)。该特异性结合元件优选包括位于特异性结合元件的恒定结构域的结构环中的PD-L1抗原结合位点。该特异性结合元件例如在癌症、以及感染性疾病、炎症、与炎症相关联的疾病和病症、及炎性疾病的治疗中获得应用。