Monoclonal neutralizing antibody of HPV52L1 and application of monoclonal neutralizing antibody

The invention relates to the technical field of antibody drugs, in particular to a monoclonal neutralizing antibody of HPV52L1 and an application thereof. The invention provides a specific monoclonalneutralizing antibody of HPV52 and a hybridoma cell line of generating the antibody. One monoclonal neutralizing antibody with the highest neutralization activity titer can be widely applied to detection of HPV52 virus infection in clinical samples by using an indirect ELISA method, a double-antibody sandwich ELISA method, an immunological hybridization method and the like; and the monoclonal neutralizing antibody with the highest neutralization activity titer can be used to prepare a vaginal gel, a vaginal cleaning fluid, a topical lotion, a vaginal suppository, freeze-dried powder, a vaginaleffervescent tablet and the like, is applied to treatment of HPV52 infection patients and can effectively improve the clinical negative conversion rate of the HPV52 patients. The monoclonal neutralizing antibody is of great s